Table 2.

Altered protein expression between in K562 cells after treatment with imatinib or its derivates. +, indicates identified proteins. −, indicates proteins that have not been identified. ↓ and ↑ indicate proteins that are down or up-regulated, respectively, upon inhibitor treatment.

Accession	Protein Name	Localization	SK23	SK16	SK20	Y18	Imatinib
Amino acid biosynthesis
O43175	D-3-phosphoglycerate dehydrogenase	cytoplasm	+	+	+	↑	+
Apoptosis-cell cycle
P61289	Proteasome activator complex subunit 3	nucleus	−	−	−	↓	−
Q00526	Cyclin-dependent kinase 3	cytoplasm	↑	−	+	+	−
Q92688	Acidic leucine-rich nuclear phosphoprotein 32 family member B	cytoplasm	↓	+	+	+	+
DNA and RNA related proteins
Q16630	Cleavage and polyadenylation specificity factor subunit 6	nucleus	+	+	+	↓	+
P22087	rRNA 2'-O-methyltransferase fibrillarin	nucleus	+	+	+	↓	+
Q9NR30	Nucleolar RNA helicase 2	nucleus	↑	+	+	↓	+
Q08211	ATP-dependent RNA helicase A	cytoplasm	+	+	+	↓	+
Other
P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	centromere	↓	+	+	+	+
P09622	Dihydrolipoyl dehydrogenase,	mitochondrion	+	+	↑	↑	+
Q96EP5	DAZ-associated protein 1	cytoplasm	+	+	+	↓	+
P13646	Keratin, type I cytoskeletal 13	intermediate filament	↓	−	−	−	−
P49327	Fatty acid synthase	cytoplasm	+	+	↓	↓	+
P07237	Protein disulfide-isomerase	cell memb.	↑	+	↑	↑	+
P49915	GMP synthase [glutamine-hydrolyzing]	cytoplasm	+	+	+	↓	+
Host-virus interaction
O00571	ATP-dependent RNA helicase DDX3X	cytoplasm	↑	↑	↑	↑	↑
Q13435	Splicing factor 3B subunit 2	nucleus	↑	+	+	+	+
Protein biosynthesis
Q15084	Protein disulfide-isomerase A6	cell memb.	+	+	↑	+	+
P41567	Eukaryotic translation initiation factor 1	cytoplasm	↑	+	↑	↑	+
O60739	Eukaryotic translation initiation factor 1b	unknown	↓	+	↓	+	+
Signal transduction
P49006	MARCKS-related protein	cell memb.	↑	+	+	+	↑
P30101	Protein disulfide-isomerase A3	en reticulum	+	+	↑	+	+
Stress response
Q14011	Cold-inducible RNA-binding protein	cytoplasm	+	↑	+	↑	+
P98179	Putative RNA-binding protein 3	cytoplasm	−	↑	−	↑	−
Q9Y4L1	Hypoxia up-regulated protein 1	en reticulum	+	+	↑	↑	+
Transcription
P43243	Matrin-3	nucleus	+	+	+	↓	+
Q96AE4	Far upstream element-binding protein 1	nucleus	+	+	+	↓	+
Transport
Q9UN86	Ras GTPase-activating protein-binding protein 2	cytoplasm	−	↓	+	−	−
Unknown
Q5T1J5	Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9,	mitochondrion	↓	↓	↓	↓	↓
Q9Y6H1	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2	mitochondrion	↓	↓	↓	↓	↓
Q9BQ39	ATP-dependent RNA helicase DDX50	nucleus	↑	+	+	↓	+
Q13067	G antigen 3	unknown	+	+	+	↓	↓
Q13069	G antigen 5	unknown	+	+	+	↓	↓
Q13070	G antigen 6	unknown	+	+	+	↓	↓