Skip to main content
. 2014 Jul 29;2(3):382–398. doi: 10.3390/proteomes2030382

Figure 4.

Figure 4

Altered processing and subcellular distribution of filaggrin intermediates. (A) Exposure to low-dose ionizing radiation (LD-IR) results in the accumulation of higher molecular weight filaggrin intermediates in whole tissue lysates; (B) Each subcellular fraction contains different filaggrin antibody-reactive bands, indicating that radiation affects both proteolytic processing and subcellular localization of specific filaggrin monomers; (C) Altered abundance of filaggrin peptides in each subcellular compartment.