Table 1. Correlation of ASS1 Expression and Clinicopathologic Parameters in Untreated Group and Treated Groups.
| Untreated | Treated | |||||
|---|---|---|---|---|---|---|
| Characteristics | ASS1-low (%) (n = 16) | ASS1-high (%) (n = 119) | p value | ASS1-low (%) (n = 18)* | ASS1-high (%) (n = 104)* | p value |
| Gender | 0.64 | 0.91 | ||||
| Female | 6 (37.5) | 52 (43.7) | 7 (38.9) | 42 (40.4) | ||
| Male | 10 (62.5) | 67 (56.3) | 11 (61.1) | 62 (59.6) | ||
| Age | 0.55 | 0.42 | ||||
| <60 | 6 (37.5) | 33 (27.7) | 9 (50) | 41 (39.4) | ||
| 60–70 | 7 (43.8) | 49 (41.2) | 7 (38.9) | 37 (35.6) | ||
| >70 | 3 (18.7) | 37 (31.1) | 2 (11.1) | 26 (25) | ||
| Tumor differentiation | 0.07 | 0.06 | ||||
| Well-moderate | 8 (50) | 86 (72.3) | 8 (44.4) | 70 (67.3) | ||
| Poor | 8 (50) | 33 (27.3) | 10 (55.6) | 34 (32.7) | ||
| Tumor size | 0.02 | 0.8 | ||||
| ≤2.0 cm | 0 (0) | 19 (16.0) | 4 (22.2) | 26 (25.0) | ||
| >2.0 cm | 16 (100) | 100 (84.0) | 14 (77.8) | 78 (75.0) | ||
| AJCC stage | 0.24 | 0.84 | ||||
| Stage IIA | 2 (12.5) | 31 (26.1) | 6 (33.3) | 33 (31.7) | ||
| Stage IIB | 14 (87.5) | 88 (73.9) | 12 (66.7) | 69 (66.3) | ||
| Lymph node status | 0.24 | 0.98 | ||||
| Negative | 2 (12.5) | 31 (26.1) | 6 (33.3) | 35 (33.7) | ||
| Positive | 14 (87.5) | 88 (73.9) | 12 (66.7) | 69 (66.3) | ||
| Recurrence | 0.045 | 0.44 | ||||
| No recurrence | 1 (6.3) | 32 (26.9) | 3 (17.7) | 27 (26.2) | ||
| Local recurrence | 6 (37.5) | 19 (16.0) | 5 (29.4) | 23 (22.3) | ||
| Distant recurrence | 9 (56.2) | 68 (57.1) | 9 (52.9) | 53 (51.5) | ||
| Margin status | 0.78 | 0.06 | ||||
| Negative | 14 (87.5) | 101 (84.9) | 14 (77.8) | 96 (92.3) | ||
| Positive | 2 (12.5) | 18 (15.1) | 4 (22.2) | 8 (7.7) | ||
* Due to unavailability of recurrence data, one patient is taken out from ASS1-low and ASS-high groups, respectively.