Table 2. Optimal Ki-67 cutoff values for predicting tumor recurrence.

Cutoff value*	Sensitivity	Specificity	Relative risk	95% CI	P value
Average method
<17% vs ≥17%	67.86%	60.65%	1.7242	1.3047–2.2786	0.0001
<18% vs ≥18%	67.86%	63.44%	1.8561	1.4005–2.4599	< 0.0001
<19% vs ≥19%	60.71%	65.81%	1.7756	1.2848–2.4539	0.0005
Hot spot method
<22% vs ≥22%	75.00%	60.00%	1.8750	1.4733–2.3862	< 0.0001
<23% vs ≥23%	64.29%	62.37%	1.7082	1.2656–2.3054	0.0005
<24% vs ≥24%	64.29%	64.52%	1.8117	1.3394–2.4506	0.0001

*Cutoff values were obtained based on ROC curve analyses.

Abbreviation: CI, confidence interval