Fig 2. Modules and roles of the nodes of the HCV-Human PPI network.

The network was produced using the procedures described in Fig 1A–1C, with the modules and the roles of network nodes determined by NetCarto (see Methods). The three types of network nodes are represented as triangles for SLiMs; circles for VIPs_direct; and squares for VIPs_indirect. Their network roles (R7 to R1) are depicted as symbols of decreasing size. All nodes are color-coded according to their module. A representative function(s) of each module was derived from an enrichment analysis of GO terms associated with its nodes followed by a summary of Revigo representatives [21] (see Methods and S1 Table). Colored in gray in the lower right corner are eight isolated nodes.