Table 1. Patient sample, age, sex, fibrosis staging (Scheuer score) and SHH expression.
Tissue | Age (time tx) | Sex | Fibrosis stage | SHH: hepatocyte | SHH: non-parenchymal | SHH+ EpCAM+ |
---|---|---|---|---|---|---|
donor | 54 | F | F = 0 | Negligible | Yes | Yes |
donor | 23 | F | F = 0 | Yes | Yes | |
donor | 64 | M | F = 0 | Yes | Yes | |
donor | 83 | M | F = 0 | Yes | Yes | |
donor | 60 | M | F = 0 | Yes | Yes | |
ALD | 62 | M | F = 4 | E-M interface | Yes | n/a |
ALD | 60 | M | F = 4 | E-M interface | Yes | n/a |
ALD | 62 | M | F = 4 | Widespread: nodule + interface | Negligible | Yes |
ALD | 45 | M | F = 4 | Widespread: nodule + interface | Yes | Yes |
ALD | 47 | M | F = 4 | E-M interface | Yes | n/a |
ALD | 56 | M | F = 4 | High expression E-M interface | Yes | Weak |
NASH | 64 | M | F = 4 | Widespread: nodule + interface | Yes | Weak |
NASH | 52 | M | F = 4 | High expression E-M interface | Yes | Yes |
NASH | 67 | M | F = 4 | High expression E-M interface | Yes | Yes |
PBC | 60 | M | F = 3 | Low expression | Yes | Yes |
Abbreviations: Tx, transplant; ALD, alcoholic liver disease; NASH, non-alcoholic steatohepatitis; PBC, primary biliary cirrhosis; E-M, epithelial-mesenchymal interface