Table 4. Common gene changes in BMOL1.2 and BMOL-TAT cells following GANT61 treatment.
| BMOL1.2 | BMOL-TAT | COMBINED ANALYSIS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene ID | 1 | 2 | 3 | fold change | p-value | 4 | 5 | 6 | fold change | p-value | fold change | p-value |
| Afp | -116.1 | -22.7 | -15.65 | 0.1612 | 14.1 | -38.0 | 40.3 | - | - | -2.52 | 0.45926 | |
| Alb | -4.5 | -4.8 | -2.94 | 0.0701 | -1.7 | - | - | -2.06 | 0.02770 | |||
| Bcl2 | -2.1 | -1.5 | -1.9 | -1.82 | 0.0806 | - | - | - | - | |||
| Bmp7 | -54.4 | -25.6 | -10.41 | 0.2516 | -7.4 | -5.1 | -3.815 | 0.288082 | -6.30 | 0.09271 | ||
| Cdkn2a | - | - | -2.4 | -1.5 | -1.9 | -1.924 | 0.324337 | -1.54 | 0.18022 | |||
| Cdon | -1.7 | -3.2 | -2.2 | -2.29 | 0.0025 | -2.1 | -2.2 | -2.4 | -2.251 | <0.0001 | -2.27 | <0.0001 |
| Col1a1 | -2.6 | -3.6 | -21.1 | -5.79 | 0.0131 | -2.0 | -3.0 | -3.7 | -2.806 | 0.087278 | -4.03 | 0.00101 |
| G6pc | -53.1 | -32.3 | -13.56 | 0.1231 | 28.2 | - | - | -2.52 | 0.51636 | |||
| Glul | - | - | -1.7 | -1.6 | -1.555 | 0.099958 | - | - | ||||
| Hes1 | -1.6 | -2.3 | -1.7 | -1.83 | 0.0042 | -2.4 | -1.9 | -2.4 | -2.216 | 0.000364 | -2.02 | 0.00032 |
| Hey1 | -1.6 | -2.2 | -1.64 | 0.0645 | -2.0 | -1.6 | -2.0 | -1.859 | 0.017316 | -1.75 | 0.00079 | |
| Hgf | -1.6 | -10.9 | -2.81 | 0.3902 | 5.8 | - | - | - | - | |||
| Hnf1a | - | - | -1.7 | -1.8 | -1.569 | 0.169875 | - | - | ||||
| Hnf4a | -2.3 | - | - | -1.9 | -2.3 | -1.6 | -1.925 | 0.1736 | -1.74 | 0.12746 | ||
| Ihh | -2.0 | -2.4 | -1.59 | 0.2345 | -3.2 | - | - | -1.83 | 0.23362 | |||
| Krt7 | -2.0 | -3.8 | -3.4 | -2.96 | 0.0413 | - | - | -1.91 | 0.60786 | |||
| Krt8 | - | - | -2.3 | -1.7 | -2.2 | -2.074 | 0.026401 | -1.56 | 0.08193 | |||
| Krt19 | -1.9 | - | - | -1.8 | -2.2 | -1.815 | 0.218108 | -1.60 | 0.29123 | |||
| Lgr5 | -1.9 | -101.7 | -37.5 | -19.50 | 0.1928 | -6.2 | 31.3 | -48.6 | - | - | -6.45 | 0.13103 |
| Ly6a | -2.9 | -6.7 | -3.1 | -3.91 | 0.0137 | -4.7 | -4.5 | -3.0 | -3.996 | 0.017748 | -3.95 | 0.00302 |
| Notch1 | -1.5 | -3.8 | -2.0 | -2.27 | 0.0151 | -2.1 | -2.7 | -2.4 | -2.370 | 0.06564 | -2.32 | 0.00661 |
| Onecut1 | -8.9 | -4.6 | -3.47 | 0.0931 | -3.9 | -2.8 | -2.7 | -3.088 | 0.006028 | -3.27 | 0.00130 | |
| Ptch1 | - | - | -1.7 | -1.6 | -1.526 | 0.030954 | - | - | ||||
| Shh | 8.9 | 16.9 | - | - | -2.4 | -2.5 | -2.0 | -2.289 | 0.379243 | - | - | |
| Spp1 | -2.3 | -4.6 | -2.1 | -2.80 | 0.0221 | -2.1 | -2.8 | -2.7 | -2.513 | 0.051541 | -2.65 | 0.07831 |
| Stk36 | -2.7 | -1.9 | -1.94 | 0.0052 | -1.8 | -1.9 | -1.9 | -1.855 | 0.006206 | -1.90 | <0.0001 | |
| Ttr | -13.2 | -17.3 | -7.5 | -11.95 | <0.0001 | -289.9 | -4.6 | -5.5 | -19.483 | 0.029609 | -15.26 | <0.0001 |
| Wnt2 | -5.8 | -169.6 | -35.4 | -32.72 | 0.1276 | -32.0 | -63.6 | -14.4 | -30.811 | 0.20457 | -31.75 | 0.07108 |
| Wnt4 | -3.1 | -6.7 | -2.9 | -3.95 | 0.0020 | -8.0 | -4.1 | -5.0 | -5.481 | 0.000914 | -4.65 | <0.0001 |
| Wnt5b | -24.1 | -9.4 | -1.8 | -7.36 | 0.0087 | -8.6 | -2.2 | -3.315 | 0.336567 | -4.94 | 0.02858 | |
| Wnt8a | -9.6 | -4.5 | -3.97 | 0.0704 | 5.6 | 2.6 | -2.3 | - | - | - | - | |
| Zic1 | -3.2 | -1.9 | -1.95 | 0.3251 | -6.3 | -1.8 | -2.046 | 0.308904 | -2.00 | 0.11378 | ||
| Fgf9 | 2.7 | 2.5 | 1.73 | 0.5778 | 1.5 | - | - | 1.53 | 0.36967 | |||
| Foxe1 | 14.8 | 8.9 | 5.47 | 0.2500 | 25.7 | 1.8 | 3.142 | 0.3836 | 4.15 | 0.18450 | ||
| Klf4 | 2.1 | 2.0 | 1.73 | 0.0339 | - | - | - | - | ||||
| Myc | 2.2 | 2.5 | 1.88 | 0.0454 | - | - | 1.51 | 0.20080 | ||||
| Npc1 | 2.7 | 2.2 | 2.02 | 0.0209 | - | - | - | - | ||||
| Rhbg | 1.9 | -2.2 | - | - | 11.2 | 33.3 | 81.2 | 31.1411 | 0.00654 | 5.45 | 0.39536 | |
| Shh | 8.9 | 16.9 | 5.10 | 0.0681 | -2.4 | -2.5 | -2.0 | - | - | - | - | |
| Sox9 | - | - | 1.9 | 1.8 | 1.7193 | 0.067694 | 1.51 | 0.01519 | ||||
| Wnt1 | 13.3 | -56.2 | - | - | 10.8 | 23.0 | 5.5068 | 0.167538 | 1.91 | 0.45073 | ||
| Wnt7a | 2.8 | 2.1 | 2.3 | 2.38 | 0.0047 | 1.6 | 2.0 | 2.8 | 2.0569 | 0.165904 | 2.21 | 0.00326 |