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. 2017 Feb 10;12(2):e0172067. doi: 10.1371/journal.pone.0172067

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© 2017 Thompson et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) Immunohistochemistry of tenascin-C expression in cav-1 +/+ and cav-1 -/- glands at low and high magnification. Results demonstrated an increased expression of tenascin-C in the peri-ductal and adipose stroma in cav-1 -/- glands. This is in contrast to cav-1 +/+ glands where tenascin-C expression is expressed in the peri-ductal stroma and to a lesser extent in the adipose stroma. Tenascin-C was also expressed in the stromal cells in cav- 1-/- and cav-1 +/+ glands (red arrows), albeit with a greater proportion of positive cells in cav-1 -/- glands. (B) The percent expression of tenascin-C was significantly higher in cav-1 -/- glands compared to cav-1 +/+ glands. (C) The intensity of tenascin-C staining was significantly higher in cav-1 -/- glands compared to cav-1 +/+ glands. Scale bars are 50 μM and 20 μM in low and high magnification images, respectively. *p≤0.05, **p≤0.01. Tn-C: tenascin-C. Results are reported as the mean ± the SEM.