Fig 4. αSMA expression is upregulated in cav-1 -/- mammary glands.
(A) Immunohistochemistry of αSMA in cav-1 +/+ and cav-1 -/- glands at low and high magnification. Results demonstrated that αSMA expressing cells are predominantly localized to the myoepithelial compartments in cav-1 +/+ and cav-1 -/- glands. αSMA expressing cells are also observed in adipose stromal cells (arrows) in cav-1 +/+ and cav-1 -/- glands (B) The percent expression of αSMA was significantly higher in cav-1 -/- glands compared to cav-1 +/+ glands. (C) The intensity of αSMA staining was significantly higher in cav-1 -/- glands compared to cav-1 +/+ glands. Scale bars are 50 μM and 20 μM in low and high magnification images, respectively. *p≤0.05. Results are reported as the mean ± the SEM.