Table 1. Clinical and histopathological information for HPV(+) and HPV(−) HNSCC patients.
| Variable | Description | HPV(+) | HPV(−) | p-value | Test≠ |
|---|---|---|---|---|---|
| (n=10) | (n=13) | ||||
| Gender | % Male | 90.00 | 76.92 | 6.04E-01 | a |
| Age | Mean | 56.90 ± 8.66 | 63.77 ± 15.85 | 2.32E-01 | b |
| Collection site | Liverpool | 1 | 0 | ||
| Poole | 2 | 6 | 2.81E-01 | a | |
| Southampton | 7 | 7 | |||
| Sequencing Batch | 1 | 3 | 6 | ||
| 2 | 7 | 5 | 3.92E-01 | a | |
| 3 | 0 | 2 | |||
| RIN* | Mean | 8.51 ± 0.80 | 8.51 ± 1.01 | 7.56E-01 | c |
| Smoking | Non smoker | 10 | 6 | ||
| Smoker | 0 | 4 | 2.56E-02 | a | |
| Heavy smoker | 0 | 3 | |||
| Alcohol | Non drinker | 5 | 3 | ||
| Moderate drinker | 4 | 9 | 4.02E-01 | a | |
| Heavy drinker | 1 | 1 | |||
| Tumor site | Larynx | 0 | 4 | ||
| Oral | 0 | 5 | 1.60E-03 | a | |
| Oropharynx | 10 | 4 | |||
| White blood cells | Mean | 9.47 ± 2.23 | 8.52 ± 1.92 | 2.86E-01 | b |
| Lymphocytes | Mean | 1.82 ± 0.60 | 1.77 ± 0.81 | 5.76E-01 | c |
| Staging | I | 0 | 3 | ||
| II | 1 | 0 | 3.48E-01 | a | |
| III | 2 | 3 | |||
| IV | 7 | 7 | |||
| TIL status | High | 8 | 4 | 3.61E-02 | a |
| Medium | 2 | 9 | |||
| Pattern of invasion | Cohesive | 10 | 6 | 7.49E-03 | a |
| Discohesive | 0 | 7 | |||
| Differentiation | Poor | 9 | 2 | ||
| Moderate | 1 | 9 | 8.85E-04 | a | |
| Well | 0 | 2 | |||
| Smooth muscle actin | Low | 10 | 9 | ||
| Moderate | 0 | 2 | 2.37E-01 | a | |
| High | 0 | 2 | |||
| Tumor cell | % | 68.00 ± 20.58 | 65.38 ± 21.06 | 7.69E-01 | B |
| E6 expression | Mean | 4.57 ± 1.11 | −4.36 ± 0.57 | 1.75E-06 | C |
| E7 expression | Mean | 5.07 ± 1.30 | −4.36 ± 0.57 | 1.75E-06 | C |
*
RIN; RNA integrity number
≠
P-values were obtained from Fisher's exact test (a) for categorical variables. A two sample t-test (b) was performed for numerical variables with normal distribution (Shapiro-Wilk test, P≥0.05). A Wilcoxon rank sum test (c) was performed for numerical variables with non-normal distribution (Shapiro-Wilk test, P<0.05). Statistically significant p-values (<0.05) are indicated in bold.