Figure 1. Progeroid Zmpste24^−/− mice show reduced GDF11/8 plasma levels.

Western-blot analysis of GDF11/8 plasma levels of young (1.5-month-old) A. and aged (3-month-old) B. Zmpste24^−/− and wild-type mice. Note that plasma samples were obtained from the same individuals at the two time points. 2 ng of rGDF11 were loaded as a positive control. Ponceau S stained membranes of the corresponding western-blots are shown to demonstrate equivalent loading (bottom). # indicates mouse number.