Figure 1. Dexmedetomidine prevents rI/R induced lung injury and pulmonary microvascular hyper-permeability in vivo.

C57BL/6J mice were pre-treated or post-treated with dexmedetomidine (Dex) alone or in combination with a₂-adrenoceptor antagonist atipamezole (Atip) or FAK inhibitor 14 (inhibit FAK phosphorylation)followed by clamping of the bilateral renal pedicle for 45 minutes and reperfusion 24 hours. A. Example micrographs of lung tissue section under difference conditions (a: Control; b: Dex; c: Sham; d:rI/R surgery; e: Pre-Dex + rI/R surgery; f: Post-Dex + rI/R surgery; g: Atip-Dex + rI/R surgery; h: FAK inhibitor-Dex + rI/R surgery; Arrows show the erythrocytes); B. Lung injurious scores presented with Box-Whiskers plot; C. The FITC-Albumin extravasation into lung tissue. Data are mean ± SD (n = 5-6);*p < 0.05, **p < 0.01, ***p < 0.001vs.Control, ^#p < 0.05, ^##p < 0.05vs.rI/R surgery.