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Combination effects of MNKI-8e and Ara-C at different molar ratios by a 72 h cytotoxicity assay and the combination indices (i.e. CI = 1 additive effect, CI < 1 synergy or CI > 1 antagonism) are shown. The CI values were calculated by the median-effect analysis method [21, 22] and computed using the CompuSyn program (ComboSyn, Inc.).
