Figure 7. RSK1 silencing reduced the incidence of metastases in vivo in an ES orthotopical xenograft model.

A and B. Scheme and pictures depicting A673 RSK1-knockdown model after orthotopical implantation inside gastrocnemius muscle and removal of muscle after primary tumor growth. C. Lung metastasis incidence in A673 RSK1-silenced cells after primary tumor removal. D. Representative images of lungs recovered from mice orthotopically injected with A673 shRSK1 cells (magnification, ×100). Drawings in Figure 7A are adapted from graphics deposited in Wikimedia Commons and Servier Medical Art under a Creative Commons Attribution 3.0 Unported License.