Table 1. Angiogenesis-related genes associated with the presence of functional intratumoral lymphatics in PDX models of squamous cell carcinoma of the uterine cervix.
Gene refseq* | Symbol | Name** |
---|---|---|
NM_001565 | CXCL10 | Chemokine (C-X-C motif) ligand 10 |
NM_001993 | F3 | Coagulation factor III (thromboplastin, tissue factor) |
NM_002026 | FN1 | Fibronectin 1 |
NM_000618 | IGF1 | Insulin-like growth factor 1 (somatomedin C) |
NM_000576 | IL1B | Interleukin 1, beta |
NM_001400 | S1PR1 | Sphingosine-1-phosphate receptor 1 |
NM_000459 | TEK | TEK tyrosine kinase, endothelial (Tie-2) |
NM_003254 | TIMP1 | TIMP metallopeptidase inhibitor 1 |
NM_005429 | VEGFC | Vascular endothelial growth factor C |
NCBI reference sequence database.
Genes showing >2-fold higher expression in the BK-12 and LA-19 models than in the ED-15 and HL-16 models as well as >2-fold higher expression in BK-12-E tumors than in BK-12-L tumors. P < 0.05 for all genes listed in the table.