Table 2. List of affected genes in CMML patients that were studied at diagnosis and at time of AML or CMML-2 progression (n=8).

Data at diagnosis				Data at progression
Diagnosis	N of genes	Gene	Mutation Freq. (%)	Progression	N of genes	Gene	Mutation Freq. (%)
CMML-1	5	SETBP1	45	CMML-2	5	SETBP1	49
		UMODL1	46			UMODL1	47
		SH2B3	43			SH2B3	41
		SF3B1	48			SF3B1	45
		GATA2	46			GATA2	41
CMML-1	5	ASXL1	49	AML	5	ASXL1	47
		UMODL1	50			UMODL1	51
		CDH3	40			CDH3	20
		NRAS	15			NRAS	6
		PTPN11	6
						BRAF	9
CMML-1	2	RUNX1	52	AML	4	RUNX1	52
		TET2	45			TET2	43
						SRSF2	24
						FLT3	22
CMML-1	3	TET2	47	AML	6	TET2	48
		CBL	36			CBL	5
		ASXL1	43			ASXL1	46
						KMT2D	51
						KRAS	42
						AEBP2	32
CMML-2	3	JARID2	51	AML	4	JARID2	48
		TET2	44			TET2	43
		NPM1	31			NPM1	30
						GNAS	20
CMML-2	6	ASXL1	52	AML	6	ASXL1	49
		CSF3R	51			CSF3R	47
		SRSF2	41			SRSF2	12
		TET2	44			TET2	46
		NRAS	47			NRAS	47
		EZH2	39			EZH2	43
CMML-2	2	ASXL1	43	AML	4	ASXL1	48
		ZRSR2	19			ZRSR2	22
						KMT2D	22
						PTPN11	9
CMML-2	3	ASXL1	34	AML	4	ASXL1	39
		RUNX1	45			RUNX1	50
		NF1	6			NF1	8
						NRAS	5

Genes that are only affected at time of diagnosis or progression are highlighted in bold