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. 2016 Jun 14;7(35):57277–57289. doi: 10.18632/oncotarget.10031

Figure 2. Preferential uptake and retention of MHI-148 dye in human gastric cancer subcutaneous and orthotopic xenograft models.

Figure 2

A. Dual BLI/NIRF imaging of SGC −7901 cell-derived tumor xenografts in subcutaneous models. Different numbers of luc-tagged SGC-7901 cells were injected into nude mice to establish subcutaneous tumor xenografts. Two weeks later, tumor-emitting signals by both BLI and NIRF imaging were captured. Representative images are shown. B. The correlation of BLI/NIRF signal intensity in A was determined (n=5 for each group). The mean was used to plot the correlation curves. C. Dual BLI/NIRF imaging of SGC-7901 cell-derived tumor xenografts in orthotopic models. Luc-tagged SGC-7901 cells were injected in the stomach serosa of nude mice to establish orthotopic xenografts. BLI and NIRF signals in mice subjected to both imaging modalities were detected on Day 14, 19, 24 and 29. Representative images are shown. D. The correlation of BLI/NIR signal intensity in C was determined (n=5 for each group). The mean was used to plot the correlation curves.