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. 2016 Jun 14;7(35):57327–57350. doi: 10.18632/oncotarget.10033

Figure 1. Representative proteins involved in DNA methylation and histone modifications that were identified to be recurrently mutated, translocated or aberrantly recruited in hematological malignancies.

Figure 1

The consequences of mutations, either gain of function or loss of function are also shown. Gene symbol: CBP, cyclic AMP response element-binding protein; DNMT, DNA methyltransferase; DOT1L, disruptor of telomeric silencing 1-like; EZH2, enhancer of zeste 2; H3K4, histone 3 lysine 4; H3K9, histone 3 lysine 9; H3K27, histone 3 lysine 27; H3K36, histone 3 lysine 36; H3K79, histone 3 lysine 79; H4R3, histone 4 arginine 3; HDAC, histone deacetylase; IDH, isocitrate dehydrogenase; MLL, mixed-lineage leukemia; MOZ, monocytic leukemia zinc finger protein; NSD, nuclear-receptor-binding SET-domain-containing; PRMT, protein arginine N-methyltransferase; RIZ, retinoblastoma protein-interacting zinc finger; TET2, Ten-Eleven-Translocation 2.