Table 1. Expression of SERPINE1, uPA and uPAR as prognostic factors in head and neck cancer studies.

Study	uPA/uPAR/SERPINE1	Protein/RNA	Tumor vs Normal	Prognostic significance	Type	N
Pavon et al 2015 [62]	SERPINE1	Protein/RNA	Over-expressed	Poor prognosis	Re-/prospective	80 & 190
Pasini et al 2001 [117]	uPA/ SERPINE1	RNA	Over-expressed	------	Prospective	91
Speleman et al 2007 [118]	uPA/SERPINE1	Protein	Over-expressed	Poor prog. (SERPINE1)	Prospective	46
Yasuda et al 1997 [127]	uPA/SERPINE1	Protein	-----	-----	NA	28
Lindberg et al 2006 [116]	uPAR/SERPINE1	Protein	Over-expressed	-----	Retrospective	20
Nozaki et al 1998 [27]	uPA/uPAR/SERPINE1	Protein	-----	------	NA	34
Strojan et al 1998 [124]	uPA/SERPINE1	Protein	Over-expressed	-----	Prospective	58
Chin et al 2005 [128]	uPA/SERPINE1	Protein	Over-expressed	Poor prognosis	NA	62
Huang et al 2014 [84]	SERPINE1	Protein	Over-expressed	NS	Retrospective	43
Magnussen et al 2014[130]	uPAR/SERPINE1	Protein	Over-expressed	Poor prognosis	Retrospective	115
Dhanda et al 2014 [61]	SERPINE1	Protein	Over-expressed	Poor prognosis	Prospective	112
Hundsdorfer et al 2005 [131]	uPA/SERPINE1	Protein	Over-expressed	Poor prognosis	Prospective	79
Strojan et al 2000 [141]	uPA/SERPINE1	Protein	---	Poor prognosis (uPA)	NA	47
Yoshizawa et al 2011 [140]	uPA/uPAR	Protein	----	Poor prognosis	Retrospective	54

N:number of patients included in each study ; NS:non-significant; NA.: not available