Table 2. Summary of epigenetic regulation of myeloid derived suppressor cells (II).

Epigenetic modulation	Target gene or pathway	Effect on MDSCs	Disease/model	Species	Reference
miR-146a	IRAK1/TRAF6/NF-kB pathway	inhibit expansion	Immune deficiency	mice	[68, 69]
miR-424	PU.1/ NFI-A	promote differentiation	acute promyelocytic leukemia	human	[70]
miR-181b	CYLD, NF-kB	promote proliferation and accumulation	acute promyelocytic leukemia	human	[71]
miR-34a	N-myc	inhibit apoptosis and induce expansion	chimera	mice	[72]
A20 siRNA	A20	induce apoptosis and inhibit immunosuppression	EG7 T lymphoma/B16-F10 melanoma cell inoculation	mice	[78]
STAT3 siRNA	STAT3-arginase 1	abrogate immunosuppressive function	Head and neck squamous cell carcinoma (HNSCC)/prostate cancer	human	[80],[81]
SCF siRNA	Stem cell factor (SCF)	reduce expansion and accumulation	MCA26 colon cancer with liver metastases	mice	[89]
CK2 siRNA	caseine kinase 2 (CK2)-Notch signaling	improve differentiation and reduce expansion	EL4 lymphoma/CT26 colon carcinoma/Meth A sarcoma cell inoculation	mice	[92]
THC mediated DNA methylation	Arginase-1 and STAT3	promote differentiation and immunosuppressive function	none	mice	[44]
Histone deacetylase inhibition by TSA	Not mentioned	promote expansion	none	mice	[50]
HDAC11	Not mentioned	negative regulator of MDSC expansion and function	EL4 lymphoma cell inoculation	mice	[52]
HDAC2	Rb1	Phonotype switch	EL-4 thymoma, Lewis Lung Carcinoma (LLC) and 4T1 mammary carcinoma inoculation	mice	[54]