Table 1.
Group | Rheobase (pA) | Resting Membrane Potential (mV) |
Action Potential Amplitude (mV) |
After Hyperpolarization Amplitude (mV) |
Action Potential Width at 0 mV (ms) |
Action Potential Rise time (ms) |
Action Potential Falling time (ms) |
---|---|---|---|---|---|---|---|
Vehicle | 195.5 ± 31.03 | −52.51 ±1.32 | 99.56 ± 3.11 | −7.94 ±1.14 | 5.68± 0.42 | 3.01± 0.32 | 12.01 ± 1.17 |
Paclitaxel Day 7 | 48.46 ± 8.44*** | −48.5 ± 0.84* | 87.79 ± 2.58** | −13.67 ± 0.97*** | 4.84 ± 0.36* | 4.0 ±0.35* | 11.88 ± 1.44 |
Paclitaxel Day 14 | 65.8 ± 6.9*** | −51.11 ± 1.03 | 89.04 ± 2.91* | −15.07 ± 1.02*** | 3.68 ± 0.19*** | 2.24 ± 0.13* | 7.63 ±0.61*** |
P < 0.05,
p < 0.01,
p < 0.001 vehicle versus paclitaxel.