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. 2017 Feb 1;26(2):243–257. doi: 10.3727/096368916X693031

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Figure 2. — MicroRNA 133b (miR-133b)-enriched exosomes further increase neurite remodeling and synaptic plasticity in the ischemic boundary zone (IBZ) compared to control multipotent mesenchymal stromal cell (MSC) exosomes. Bielschowsky silver and Luxol fast blue double staining (A row), SMI 31 immunostaining (B row), and synaptophysin immunostaining (C row) show that based on the increase of neurite remodeling and synaptic plasticity in the IBZ by the MSCs infected with blank vector (Ex-Con) treatment, the exosomes isolated from miR-133b-overexpressing MSC (Ex-miR-133b⁺) treatment further increased neurite remodeling and synaptic plasticity in the IBZ. PBS, middle cerebral artery occlusion (MCAO) rats treated with phosphate-buffered saline (PBS); CON⁺, MCAO rats treated with Ex-Con; 133b⁺, MCAO rats treated with Ex-miR-133b⁺. ∗p < 0.05, compared to PBS; #p < 0.05 compared to CON⁺, respectively. Mean ± standard error (SE), n = 6/group. Scale bars: 100 μm.