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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Pain. 2017 Mar;158(3):488–497. doi: 10.1097/j.pain.0000000000000788

Figure 1. Experimental design.

Figure 1

(a) Twenty-two rats were included in the study and imaged 2 days before the surgery as baseline. Rats were then randomized and underwent peripheral neuropathic (SNI, N = 12) and sham (N = 10) surgeries, and imaged again at 5 and 28 days post surgery. Tests for paw withdrawal threshold were performed the day before each scan. (b) SNI rats displayed tactile allodynia for stimuli applied to the neuropathic injured paw, at 5 and 28 days after surgery. No significant change in paw withdrawal threshold was observed in the healthy paw in either SNI or sham rats. (c) fMRI scan with periodic air-puff stimulation had 6 repetitive stimulus blocks. Each block consisted of stimulation alternated with 8sec-off/12sec-on/30sec-off. (d) fMRI scans were conducted when rats received 1g or 3g air-puffs to left (injury site) or right (healthy) paw. The 4th condition was expected to produce allodynia behavior after SNI surgery.