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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Pain. 2017 Mar;158(3):488–497. doi: 10.1097/j.pain.0000000000000788

Figure 4. Brain activity associated with tactile allodynia.

Figure 4

(a) Group difference in brain activity between day 28 and baseline in response to 3g air-puff stimulation on the injured paw in the SNI rats (paired t-test, with voxel-wise cluster-forming threshold of Z > 2.3 and cluster significance threshold of p < 0.05 corrected for multiple comparisons; N =7). (b) BOLD magnitude of NAc in SNI and sham rats is significantly different between the groups over time. (c) BOLD signal of NAc in SNI rats to the identical stimulation at baseline and 28 days post-surgery. (d) BOLD magnitude of OFC in SNI and sham rats is significantly different between the groups over time. (e) BOLD signal changes in OFC of SNI rats to the identical stimulation at baseline and 28 days post-surgery. Abbreviation: mPFC – medial frontal cortex, OFC – orbital frontal cortex, NAc – nucleus accumbens, b – baseline, day28 – 28 days post-surgery and also refer to abbreviations in Figure 2.