Table 2.
Adjusted difference in cerebral vasoreactivity (measured with breath holding index) by HIV infection and other risk factors among all participants (total observations, left + right sides, N=168)a
| Difference in breath holding index (% change in mean flow velocity per second) (95% CI) |
P value | |
|---|---|---|
| HIV infection | At total cholesterol of 5.15 mmol/Lb: −0.05 (−0.23 to +0.14) |
0.64 |
| At total cholesterol of 4.15 mmol/Lb: −0.28 (−0.52 to −0.05) |
0.019 | |
|
| ||
| Demographics | ||
|
| ||
| Age (per 10 years) | −0.07 (−0.15 to +0.001) | 0.055 |
|
| ||
| Female sex | −0.04 (−0.24 to +0.16) | 0.70 |
|
| ||
| Vascular and other risk factors | ||
|
| ||
| Statin use | +0.23 (−0.04 to +0.51) | 0.096 |
|
| ||
| Coronary heart disease/myocardial infarction | −0.33 (−0.69 to +0.04) | 0.080 |
|
| ||
| Antiplatelet or anticoagulation use | +0.26 (−0.11 to +0.63) | 0.11 |
|
| ||
| Tobacco use | +0.15 (−0.02 to +0.32) | 0.078 |
|
| ||
| Laboratories | ||
|
| ||
| Total cholesterol (per 1 mmol/L) | −0.22 (−0.40 to −0.05) | 0.011 |
a
Adjusted for factors listed in the column in addition to the change in mean arterial pressure between baseline and breath holding
b
P value for interaction term between HIV and cholesterol level, p=0.015