Table 3.
Adjusted difference in cerebral vasoreactivity (measured with breath holding index) by HIV-related and other risk factors among HIV-infected participants (total observations, left + right sides, N=133)a
| Difference in breath holding index (% change in mean flow velocity per second) (95% CI) |
P value | |
|---|---|---|
| Demographics | ||
|
| ||
| Age (per 10 years) | −0.08 (−0.15 to −0.01) | 0.036 |
|
| ||
| Vascular and other risk factors | ||
|
| ||
| Statin use | +0.25 (−0.05 to +0.54) | 0.097 |
|
| ||
| Coronary heart disease/MI | −0.44 (−0.78 to −0.11) | 0.009 |
|
| ||
| HIV-related factors | ||
|
| ||
| Duration of HIV infection (per year) | −0.06 (−0.13 to +0.01) | 0.078 |
|
| ||
| Duration of antiretroviral therapy (per year) | +0.08 (+0.001 to +0.16) | 0.048 |
|
| ||
| Current antiretroviral therapy: | ||
| Efavirenz | Reference | — |
| Nevirapine | −0.13 (−0.28 to +0.02) | 0.088 |
| Lopinavir/ritonavir | −0.24 (−0.47 to −0.01) | 0.040 |
a
Adjusted for factors listed in the column in addition to the change in mean arterial pressure between baseline and breath holding