Mean ± SD values of blood concentration of potassium, PaO2, HCO3−, lactate, and base excess before and during the 7th minutes of either KCN infusion 0.75 mg/kg/min (black-bars, n=4) or infusion of an equimolar solution of KCl (11.5 µmol/kg/min, gray bars, n=5). #, significant difference between KCl and KCN at 7 min, P<0.05. Note that changes in blood concentration of potassium were trivial during KCN and that KCN infusion was associated with a decrease in HCO3- along with a base deficit averaging −20 mmol/l reflecting the profound circulatory shock and possibly impediment of mitochondrial respiration.