Table 3.
VBM analysis including association of variance between 5-HTTLPR polymorphisms and GM volumes in OCD patients and HCs
| Regions | Brodmann area | Cluster size | Z | Talairach coordinates |
|---|---|---|---|---|
| x, y, z (mm2) | ||||
| Main effects | ||||
| Diagnosis effects (P < 0.05, FWE, 〈k〉 = 77.666) | ||||
| R hippocampus (OCD patients < HCs) | 763 | 5.08 | 33, −16, −18 | |
| L precentral gyrus (OCD patients > HCs) | 4 | 797 | 4.88 | −28, −27, 64 |
| Genotype effects | ||||
| No suprathreshold clusters | ||||
| Genotype-diagnosis interaction effects (P < 0.001, uncorrected, 〈k〉 = 63.146) | ||||
| R frontal pole | 10 | 112 | 4.35 | 26, 50, −6 |
R right, L left, FWE family-wise error, 〈k〉 expected voxels per clusters