Fig. 3.

Relationship between expression levels and gene conservation. Drosophila genes that are conserved in the human genome at different confidence levels (i.e., different DIOPT scores) were analyzed by DGET. We found that across all tissues, expression levels correlate with confidence in the ortholog relationship. That is, in general, genes with higher DIOPT scores vs. human genes have higher expression levels. Genes with DIOPT scores of 7–10 (light purple bars) have similar expression patterns as compared with Drosophila essential genes (dark purple bars); i.e., in both cases, the genes are likely to be expressed in many or all tissues