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. 2017 Feb 10;18:148. doi: 10.1186/s12864-017-3546-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Tuning regulation of WNT, TGF-β, Hedgehog and MAPK pathways during additional molar morphogenesis from E50 to E70. a Down-regulated WNT, TGF-β and MAPK pathways from E50 to E60, and up-regulated WNT, TGF-β and Hedgehog (HH) pathways from E60 to E70. b Heatmap showing the dynamics of differential genes participating in the TGF-β, WNT, SHH and MAPK pathways. The results are based on sequences