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. 2017 Jan 25;7(1):160258. doi: 10.1098/rsob.160258

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — TGFβ/Activin mutants display nucleolar phenotypes. (a–e) Reduced Activin activity induces nucleolar expansion. (a) Control nuclear and nucleolar staining (w1118). (b) put mutant combination (put¹³⁵/put¹⁰⁴⁶⁰) grew at a permissive temperature (18°C) and present an expansion of the nucleolar area. (c) Dpp receptor tkv mutations (tkv¹/tkv⁸) do not change the nucleolar/nuclear ratio. (d) A weak allele for the Activin receptor type I baboon (babo^k16912) shows a small expansion of the nucleolar area. (e) The heteroallelic combination of baboon (babok¹⁶⁹¹²/babo³²) shows a nucleolar expansion equivalent to put mutant combinations. All the nuclei were stained with DAPI (blue) and the nucleoli with Fibrillarin (green). (f) Scatter plot represents the nucleolar accumulation of the Fibrillarin in salivary glands of the indicated genotypes (*p < 0.05; ***p < 0.001). Scale bars: 20 μm.