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. 2017 Feb 10;17:121. doi: 10.1186/s12885-017-3107-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Assessment of aggregate cohesion, stiffness, and viscosity in response to PD0325901 treatment. Surface tension measurements for GBM-1-4 aggregates generated using standard TCM and treated with either DMSO or PD0325901. n = 20, pair-wise comparison by Student t-test, p > 0.05 (a). Surface tension measurements of GBM-3 aggregates generated in fibronectin-depleted medium supplemented with 300 μg/ml of human fibronectin. n = 20, pair-wise comparison by Student t-test, p < 0.0001 (b). Stiffness (c) and viscosity (d) data for GBM-3 aggregates generated in fibronectin-depleted medium supplemented with either 30 μg/ml or 300 μg/ml human fibronectin. Asterisks represent statistical significance by pair-wise Student t-test, p < 0.05. Note significant increase in stiffness and viscosity in response to increased concentrations of fibronectin