Table 4.
Meta-regression model of sensitivity analysis with 30-day mortality for conventional and goal-directed fluid therapy
| Variable | CFM | GDT |
|---|---|---|
| Targeting urine output | 0.56 (0.29-1.11) | 0.68 (0.34-1.36) |
| Intensive Care setting (reference) | ||
| Intraoperative setting | 0.16 (0.08-0.30) | 0.14 (0.08-0.24) |
| Postoperative setting | 0.07 (0.03-0.16) | 0.17 (0.05-0.57) |
| Transpulmonary thermodilution (reference) | ||
| Esophageal Doppler | 0.61 (0.23-1.60) | |
| Pulmonary artery catheter | 1.80 (0.51-6.33) | |
| Other monitoring devices | 0.21 (0.07-0.63) | |
| Other etiologies (reference) | ||
| Abdominal | 0.48 (0.21-1.10) | 1.14 (0.54-2.38) |
| High risk | 2.36 (0.99-5.67) | 1.19 (0.61-2.30) |
| Inotropic use | 1.43 (0.67-3.07) | 1.15 (0.47-2.81) |
| Publication year a | 0.95 (0.9-1.00) | 0.95 (0.88-1.03) |
The sensitivity analysis excluded studies in which the urine output threshold was not 0.5 ml/kg/h
aPublication year was inputted as the years from the mean publication year (2008). Data reported as odds ratio and 95% confidence interval