Table 1.
Characteristics of pancreatic cancer cases and controls.
| Cases | Controls | ORs | (95% CI) | |
|---|---|---|---|---|
| n (%) | 4113 (20.4) | 16072 (79.6) | ||
| age (mean+/− SD) yrs | 70.9 +/− 11.5 | 71.1 +/− 11.4 | ||
| Gender (n, % female) | 1,999 (48.6) | 7,794 (48.5) | ||
| obesity(n, %)1 | 861 (20.9)* | 3013 (18.7) | 1.15 | (1.06–1.26) |
| smoking(n, %)2 | 2053 (49.9)** | 6625 (41.22) | 1.52 | (1.41–1.64) |
| alcohol use (n, %)3 | 2135 (51.9)** | 7706 (48.0) | 1.23 | (1.13–1.34) |
| diabetes (n,%)4 | 931 (22.6)** | 1598 (9.9) | 2.74 | (2.50–3.01) |
| most recent PPI prescription (mean+/− SD)5 | 1.51+/− 0.85 | 1.54+/− 0.79 | 1 | (0.94–1.06) |
| Duration of follow-up (year+/− SD) | 6.33+/− 4.09 | 6.36 +/− 4.10 | 0.99 | (0.68–1.45) |
| Duration of PPI use (year+/− SD) | 2.47+/− 3.07 | 4.14 +/− 3.19 | 0.85 | (0.83–0.87) |
n, number of patients; yrs, years; SD, standard deviation; ORs, Odds Ratios; 95% CI, 95% Confidence Intervals;
1
BMI >30 mg/kg2;
2
lifetime smoker;
3
lifetime alcohol use;
4
READ code for diabetes;
5
years prior to index date;
*
p= 0.001;
**
p=<0.0001