Table 1.
Key differences between AD and CTE
| ChronicTraumatic Encephalopathy |
Alzheimer’s Disease | |
|---|---|---|
| Neurofibrillary tau tangles location: |
Layers II and III of cortex, Ammon’s Horn of Hippocampus, and Pulvinar |
Layers V and VI of cortex and CA1 of Hippocampus |
| Clinical Features | Mood disturbances and Parkinson’s like features with tangles in substantia nigra and locus ceruleus and few or no Aβ plaques |
Cognitive impairment with extracellular amyloid pathology in middle frontal, superior and middle temporal, and inferior parietal lobule |
| Anatomy | Perivascular distribution of pathology |
Severe cerebral atrophy |