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. Author manuscript; available in PMC: 2017 Feb 12.
Published in final edited form as: Curr Opin Cardiol. 2011 May;26(3):209–215. doi: 10.1097/HCO.0b013e328345986e

Figure 2. Signature chromatin domains at active and inactive gene promoters.

Figure 2

Specific chromatin marks have been characterized at active (a) and inactive (b) genes, where the arrow denotes the start of transcription. (a) Generally, activated promoters are characterized by an absence of promoter DNA methylation (CpG sites shown as black lines), an enrichment of hyperacetylated histones H3 and H4, H3K4me3 at the promoter and H3K36me3 along the transcribed region. Transcribed regions do not demonstrate H3K27me3 marks. (b) Inactive promoters are generally characterized by dense DNA methylation (shown as filled circles at CG sites), increased histone density, and enrichment of H3K27me3 and/or H3K9me3 marks.