Table 1.
A summary of histone posttranslational modifications and their effects on gene expression
| Histone modification | Location | Effect on gene expression |
|---|---|---|
| Histone H3 | ||
| K9ac | Promoter | On |
| K14ac | Promoter | On |
| K4me3 | Promoter | On |
| K9me3 | Promoter, heterochromatin | Off |
| K27me3 | Promoter, heterochromatin | Off |
| K36me3 | Transcribed region | On |
| S10phos | Promoter | On/off |
| T6phos | Promoter | Off |
| T11phos | Promoter | Off |
| Histone H4 | ||
| K5ac | Promoter | On |
| K8ac | Promoter | On |
| K12ac | Promoter | On |
| K16ac | Promoter | On |
| K20me3 | Heterochromatin | Off |
| Histone H2A | ||
| K119ub | Promoter | Off |
| Histone H2B | ||
| K120ub | Unknown | On |
ac, acetylation; K, lysine; me3, trimethylation; phos, phosphorylation; S, serine; T, threonine; ub, ubiquitination.