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Effects of age on pro-inflammatory cytokines within the brain and spleen. Fold changes from 5-month-old controls in IL-1β (A,B) and TNFα (C,D) levels in the brain (A,C) and spleen (B,D) from different ages and treatments. There were significant overall effects of age (p<.02), but no effect of ibuprofen treatment. Symbols indicate p<.05 for differences between older mice and 5 (*), 14 (#), and 20 (†) month olds with data collapsed across treatment. Mean ± SEM. N = 5-6.
