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. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Dec 3;109:26–44. doi: 10.1016/j.addr.2016.11.006

Figure 15.

Figure 15

A two-beam IMPT plan for brain tumor optimized based on criteria defined in terms of constant RBE of 1.1 (squares) and in terms of variable RBE computed using a model published by Wilkens, et al. (triangles). After optimization, both dose distributions were converted to variable RBE-weighted dose for comparison. The dose to the gross tumor volume (GTV) is more homogeneous for variable RBE-weighted optimization but lower to normal tissues to varying degrees. Notably, the dose in a 5 mm shell surrounding the GTV is reduced substantially. (Unpublished, Courtesy of Cao, University of Houston.)