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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Neurobiol Learn Mem. 2016 Aug 12;138:10–20. doi: 10.1016/j.nlm.2016.08.006

Figure 6. Summary of compartmental differences influencing cAMP and PKA dynamics.

Figure 6

(Left graphs) Interactions between “activation mechanisms” (ACs) and “inactivation mechanisms” (include PDEs and PPs) shape compartmental differences in cAMP and PKA signaling dynamics. (Right panels) Illustrations showing that AC density increases with compartment size and PDE concentrations are relatively the same in both small and large compartments. Phosphatase enrichment in small compartments may be a mechanism limiting bulk PKA activity in small dendritic compartments.