Figure 7.

Astrocyte ischemia. Effect of glucose and oxygen deprivation of astrocytes on metabolic fluxes rates calculated with random sampling approach. The global result, showed a significant increase in the tendency of the flux through anaerobic glycolysis and pentose phosphate pathway. Similarly, a reduction of the flux of the reactions grouped in the metabolic routes of fatty acids oxidation, tricarboxylic acid cycle, oxidative phosphorylation, glutamate-glutamine cycle, and Na+/K+ATPasa. (A) privation of sources of oxygen and glucose decrease gradually the synthesis of energy, until the model is unable to satisfy requirements. (B) synthesis of lactate is useful as replacement of energy until there are no sources of energy that supply pumps to interchange other metabolites. (C) pumps and transporters fluxes decrease with the energy depletion, among them glutamine (D) Acetate as an alternative source of energy is useful for model until transporters and pumps did not work by the lack of energy. (E) Detoxification properties are decreased following the energetic depletion.