Table 4.

In silico predictions of changes in metabolic functions in ischemic conditions were compared with those reported in the literature.

Name enzyme	E.C number	Model prediction	Experimental data	References
Catalase	EC:1.11.1.6	Up	Up	Gu et al., 2004; Armogida et al., 2011
Superoxide dismutase	EC:1.15.1.1	Up	Up	Baker et al., 1998
Glutathione peroxidase	EC:1.11.1.9	Up	Up	Weisbrot-Lefkowitz et al., 1998
Glyceraldehyde-3-phosphate dehydrogenase	EC:1.2.1.12	Up	Up	Tanaka et al., 2002
Hexokinase	EC:2.7.1.1	Up	Up	Niitsu et al., 1999
Nicotinamide phosphoribosyltransferase	EC:2.4.2.12	Up	Up	Yamauchi et al., 2001; Wang et al., 2011; Jing et al., 2014; Morris-Blanco et al., 2014
Phospholipase A2	EC:3.1.1.4	Up	Up	Muralikrishna Adibhatla and Hatcher, 2006
Isocitrate dehydrogenase	EC:1.1.1.42	Down	Down	Grelli et al., 2013
Monoamine oxidase	EC:1.4.3.4	Down	Down	Khvatova et al., 1997, 2007

Overall, in silico predictions of changes in metabolic function are similar to the changes reported experimentally in practices performed in astrocytes submitted to ischemia.