Figure 1.

The effect of phloretin (PT) on airway hyperresponsiveness (AHR) and cell counts in bronchoalveolar lavage fluid (BALF) of asthmatic mice. (A) Changes in AHR (Penh values) with inhalation of increasing methacholine doses (10–40 mg/ml) in normal (N) and OVA-stimulated (OVA) mice, without or with PT (PT5-20) treatment (n = 12 mice/group, measured in three independent experiments). (B) Numbers of inflammatory cells and total cells in BALF with increasing PT doses; (C) percentage of eosinophils in BALFs from OVA-sensitive mice, treated or untreated with PT. All data are presented as means ± SEM. *p < 0.05 compared to OVA control group. **p < 0.01 compared to the OVA control group. Three independent experiments were analyzed and compared with the OVA-sensitive mice.