Table 3.

NG2-glia ablation and differentiation block approaches under healthy conditions.

Cell type	Condition	Method	Efficiency	Physiological effect	Reference
NG2-glia	Health	X-irradiation	60–90%	Fast and efficient repopulation, no further effects analyzed	Chari and Blakemore, 2002; Irvine and Blakemore, 2007
		AraC infusion	Almost 100% in affected region	Fast and efficient repopulation, no further effects analyzed	Robins et al., 2013
		NG2Cre/iDTR mouse line	80%	Fast repopulation, decrease in FGF2 signaling and induction of depression like behavior	Birey et al., 2015; Birey and Aguirre, 2015
		AraC infusion, X-irradiation, genetic depletion model	50–100%	Negative effect on leptin-sensitive neurons and energy metabolism	Djogo et al., 2016
NG2-glia oligodendrocyte differentiation	Health	Genetic depletion model	∼90%	Elongation of nodes of Ranvier, deceleration of conduction velocity and motor dysfunctions	Schneider et al., 2016
		Genetic depletion model	100%	Impairment of early complex motor skill learning	McKenzie et al., 2014; Xiao et al., 2016