Table 4.

Oligodendrocyte ablation approaches under healthy conditions.

Cell type	Condition	Method	Efficiency (%)	Physiological effect	Reference
Oligodendrocytes	Health	Plp-CreERT-DTA mouse line	∼50	Demyelination, remyelination but secondary axonal damage with motor impairment and seizures	Traka et al., 2016
		MOGi-Cre/iDTR mouse line	∼60	Demyelination, gait disturbances, and tremor	Ghosh et al., 2011
		MOG-Cre;DTR mouse line	∼80	Neuropathic pain and global demyelination independent of immune system	Gritsch et al., 2014
		Mbp-DTR mouse line	26	Axonal damage without demyelination	Oluich et al., 2012
		Mbp-LacZ mouse line	∼50	Demyelination, remyelination, no functional outcome analyzed	Vanderluit et al., 2000
		MOGi-Cre/iDTR mouse line	60	Demyelination, motor dysfunctions, no autoimmunity	Locatelli et al., 2012