Figure 3. Regional plots of association results and recombination rates for new risk loci for chronic lymphocytic leukaemia.

Results shown for 1q42.13, 6p21.31, 11q23.2, 18q21.1 (a–d). Plots (drawn using visPig⁶²) show association results of both genotyped (triangles) and imputed (circles) SNPs in the GWAS samples and recombination rates. −log₁₀ P values (y axes) of the SNPs are shown according to their chromosomal positions (x axes). The sentinel SNP in each combined analysis is shown as a large circle or triangle and is labelled by its rsID. The colour intensity of each symbol reflects the extent of LD with the top genotyped SNP, white (r²=0) through dark red (r²=1.0). Genetic recombination rates, estimated using the 1000 Genomes Project samples, are shown with a light blue line. Physical positions are based on NCBI build 37 of the human genome. Also shown are the chromatin-state segmentation track (ChromHMM) for lymphoblastoid cells using data from the HapMap ENCODE Project, and the positions of genes and transcripts mapping to the region of association.