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. 2017 Feb 6;8:14175. doi: 10.1038/ncomms14175

Table 1. Summary results for SNPs associated with CLL risk.

SNP Locus Position (bp, hg19) Risk allele Data set RAF (case; control) OR 95% CI P value
rs34676223 1p36.11 23943735 C Discovery (0.74; 0.71) 1.16 (1.09; 1.22) 2.69 × 10−7
        Replication (0.74; 0.69) 1.29 (1.18; 1.42) 4.69 × 10−8
        Combined   1.19 (1.14; 1.25) 5.04 × 10−13
              I2=24% Phet=0.23
                 
rs41271473 1q42.13 228880296 G Discovery (0.81; 0.79) 1.19 (1.12; 1.26) 4.69 × 10−8
        Replication (0.82; 0.79) 1.20 (1.08; 1.34) 5.59 × 10−4
        Combined   1.19 (1.13; 1.26) 1.06 × 10−10
              I2=0% Phet=0.95
                 
rs71597109 4q24 102741002 C Discovery (0.72; 0.69) 1.17 (1.11; 1.24) 1.02 × 10−8
        Replication (0.73; 0.71) 1.15 (1.05; 1.26) 3.46 × 10−3
        Combined   1.17 (1.11; 1.22) 1.37 × 10−10
              I2=0% Phet=0.78
                 
rs57214277 4q35.1 185254772 T Discovery (0.44; 0.41) 1.14 (1.08; 1.19) 9.56 × 10−7
        Replication (0.43; 0.39) 1.12 (1.03; 1.21) 0.011
        Combined   1.13 (1.08; 1.18) 3.69 × 10−8
              I2=0% Phet=0.53
                 
rs3800461 6p21.31 34616322 C Discovery (0.13; 0.11) 1.21 (1.12; 1.31) 4.20 × 10−7
        Replication (0.12; 0.11) 1.17 (1.03; 1.34) 0.014
        Combined   1.20 (1.13; 1.28) 1.97 × 10−8
              I2=0% Phet=0.69
                 
rs61904987 11q23.2 113517203 T Discovery (0.14; 0.12) 1.23 (1.14; 1.32) 4.44 × 10−8
        Replication (0.13; 0.12) 1.26 (1.12; 1.42) 1.20 × 10−4
        Combined   1.24 (1.16; 1.32) 2.46 × 10−11
              I2=0% Phet=0.83
                 
rs1036935 18q21.1 47843534 A Discovery (0.25; 0.22) 1.17 (1.10; 1.24) 2.81 × 10−7
        Replication (0.24; 0.22) 1.11 (1.01; 1.23) 0.028
        Combined   1.15 (1.10; 1.21) 3.27 × 10−8
              I2=0% Phet=0.65
                 
rs7254272 19p13.3 4069119 A Discovery (0.20; 0.18) 1.18 (1.11; 1.26) 4.61 × 10−7
        Replication (0.19; 0.18) 1.13 (1.01; 1.26) 0.026
        Combined   1.17 (1.10; 1.23) 4.67 × 10−8
              I2=0% Phet=0.55
                 
rs140522 22q13.33 50971266 T Discovery (0.35; 0.32) 1.16 (1.10; 1.22) 2.20 × 10−8
        Replication (0.35; 0.33) 1.10 (1.01; 1.2) 0.025
        Combined   1.15 (1.10; 1.20) 2.70 × 10−9
              I2=0% Phet=0.94

bp, base pair position; CLL, chronic lymphocytic leukaemia; I2, proportion of the total variation due to heterogeneity; OR, odds ratio; Phet, P-value for heterogeneity; RAF, risk allele frequency; SNP, single-nucleotide polymorphism; 95% CI, 95% confidence interval.

RAF is risk allele frequency across all of the discovery and replication data sets, respectively. ORs are derived with respect to the risk allele. Text in bold highlight the P-value in the combined data.