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PP2A activity was regulated by α2β1 integrin on FC. (a) Analysis of PP2A activity in fibroblasts on TC or FC (p < 0.002). (b) Analysis of PP2A activity in shRNA-control or shRNA-β1 integrin transfected fibroblasts on FC (p < 0.004). (c) Analysis of PP2A activity in GD25 α2β1 integrin-null cells or GD25 reconstituted with α2β1 integrin on FC (p < 0.0001). (d) Western blots showed the protein levels of α2 and β1 integrin in GD25 without or with α2β1 integrin on FC.
