Table 1.
Roles of viral protein and RNA during viral infection in permissive cells
| Name of the vital material | Location in cell | Function |
| Viral genome + ssRNA (approximately 11000 nt) | Cytoplasm | Template for protein translation and for viral genome replication |
| Envelope, E (53 KDa)[52] | Cell membrane | Viral assembly, budding, attachment to target cells, and viral membrane fusion |
| Membrane precursor, PrM (20 KDa)[53] | Cell membrane | Facilitating E protein folding and trafficking, and virion maturation |
| Capsid, C (12 KDa)[54] | Cytoplasm | Virion maturation |
| NS1 (glycoprotein)[55] (46-55 kDa) | Endoplasmic reticulum | Subverting immune response |
| vesicular compartments, | virus-induced intracellular RNA | |
| cell surface | replication, neurovirulence | |
| NS2a (25 kDa)[56] | Transmembrane | Virus assembly, inhibit IFN-response |
| NS2b (14 kDa)[1,57] | Cytoplasm, nucleus | Viral protein cleavage |
| NS3 (69 kDa)[1] | Cytoplasm, nucleus | Viral protein cleavage, RNA |
| triphosphatase, mRNA capping, | ||
| RNA helicase | ||
| NS4a (16 kDa)[58] | Transmembrane | Viral RNA replication |
| NS4b (21.5 kDa)[59] | Integral membrane | Suppression of (IFN-α/β), |
| suppression of the host RNAi, | ||
| negatively regulate the helicase | ||
| function, viral replication | ||
| NS5 (103 kDa)[60,61] | Cytoplasm, nucleus | The RNA triphosphatase, |
| RNA-dependent RNA polymerase |