Skip to main content
. 2017 Feb 6;8:14360. doi: 10.1038/ncomms14360

Figure 5. Adipocyte FAK is required for maintenance of glucose homeostasis.

Figure 5

(a) Fasting blood glucose in male (n=9) (blue) and female (n=10) (red) control or aP2FAK−/− mice at 12 weeks of age. Fasting serum insulin (n=10) (b) and pancreas sections from 20- to 24-week-old mice stained by IHC for insulin (red; scale bar, 200 μm) with quantification (n=5 mice) (c). ITT and area above the curve (AAC) in male (n=12) (d) and female (n=10) (e) 20- to 24-week-old mice. (f) Fasting serum free fatty acid levels in 20- to 24-week-old mice (n=6). ITT and AUC in male (n=10) (g) and female (n=9) (h) 20- to 24-week-old mice fed HFD for 12–16 weeks or 6- to 8-week-old mice on db/db (n=6) (i) or ob/ob genetic background (n=9) (j). Data are mean±s.e.m. * P<0.05, **P<0.01 and ***P<0.001 by Student's t-test.